• Liver problems. Rizolung® may cause life-threatening liver injury. Your healthcare provider should do blood tests to check your liver every 2 weeks during the first 2 months of treatment with Rizolung®, then once a month and as recommended by your healthcare provider during treatment. Tell your healthcare provider right away if you develop any of the following new or worsening symptoms:
o yellowing of your skin or the white part of your eyes
o severe tiredness
o dark or brown (tea color) urine
o nausea or vomiting
o decreased appetite
o pain on the right side of your stomach
o bleed or bruise more easily than normal
o itching
• Lung problems (pneumonitis). Rizolung® may cause life-threatening lung problems. Symptoms may be similar to those symptoms from lung cancer. Tell your healthcare provider right away if you have any new or worsening symptoms, including:
o trouble breathing or shortness of breath
o cough with or without mucous
o fever
• Heart problems. Rizolung® may cause very slow, very fast, or abnormal heartbeats. Your healthcare provider may check your pulse rate and blood pressure regularly during treatment with Rizolung®. Tell your healthcare provider right away if you feel dizzy or faint or have abnormal heartbeats. Tell your healthcare provider if you take any heart or blood pressure medicines.
• Severe vision problems. Vision problems are common with Rizolung®. These problems usually happen within 1 week of starting treatment with Rizolung®. Vision problems with Rizolung® can be severe and may cause partial or complete loss of vision in one or both eyes. Your healthcare provider may hold or permanently stop your treatment with Rizolung® and refer you to an eye specialist if any vision problems develop during treatment with Rizolung®. Tell your healthcare provider right away if you have any new vision problems, loss of vision or any change in vision, including:
o double vision
o light hurting your eyes
o seeing flashes of light
o new or increased floaters
o blurry vision
In addition, for children or young adults taking Rizolung® to treat anaplastic large cell lymphoma (ALCL) or children taking Rizolung® to treat inflammatory myofibroblastic tumor (IMT): Your healthcare provider may refer you to an eye specialist before starting Rizolung®, and within 1 month of starting Rizolung® to check for vision problems. You should have an eye examination every 3 months during treatment with Rizolung® and more often if there are any new vision problems.
• Severe stomach, intestine, and mouth (gastrointestinal) problems in children or young adults with ALCL or children with IMT. Rizolung® may cause severe diarrhea, nausea, vomiting, or mouth sores. Tell your healthcare provider right away if problems with swallowing, vomiting, or diarrhea develop during treatment with Rizolung®.
o Your healthcare provider may give medicines as needed to prevent or treat diarrhea, nausea, and vomiting.
o Your healthcare provider may recommend drinking more fluids or may prescribe electrolyte supplements or other kinds of nutritional support if severe symptoms develop.
Call your healthcare provider right away if you have any of aforementioned symptoms.
The most common side effects of Rizolung® in people with NSCLC include:
The most common side effects of Rizolung® in adults with IMT include:
- ·vision problems
- ·nausea
- swelling of your hands, feet, face, or eyes
The most common side effects of Rizolung® in children with IMT include:
- diarrhea, vomiting, or nausea
- stomach-area (abdominal) pain
- rash
- ·vision problems
- upper respiratory infection
- cough
- fever
- muscle and joint pain
- tiredness
- swelling of your hands, feet, face, or eyes
- constipation
- headache
Call your doctor for medical advice about side effects.