Simerta® (Osimertinib)

Simerta ® is a kinase inhibitor of epidermal growth factor receptor (EGFR) which binds irreversibly to certain mutant forms of EGFR (T790M, L858R, and exon 19 deletions). Osimertinib also inhibited the activity of HER2, HER3, HER4, ACK1, and BLK at clinically relevant concentrations in vitro.